Scleroderma is a disease of the connective tissue featuring prominent skin thickening.  Scleroderma can lead to scarring, blood vessel problems, varying degrees of inflammation, and is apparently a manifestation of an overactive immune system. Scleroderma is classified into localized scleroderma and systemic sclerosis. CREST syndrome is a limited form of systemic sclerosis. Patients with scleroderma can have specific antibodies (ANA, anticentromere or antitopoisomerase) in their blood, which strongly suggests an autoimmune etiology.

Treatment of scleroderma is directed toward the symptom(s) that is (are) most debilitating. At Beijing Puhua International Hospital, a novel stem cell therapy was applied in a case of scleroderma, which proved to be effective.

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